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Development and preclinical pharmacology of a novel dCK inhibitor, DI-87
BACKGROUND: Deoxycytidine kinase (dCK) is an essential enzyme for production of nucleotides via the salvage pathway; DI-87 is a novel dCK inhibitor in preclinical development for use in anticancer therapy. The current study utilizes PET imaging to evaluate PK-PD relationships and to determine optima...
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| Publicado no: | Biochem Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6981055/ https://ncbi.nlm.nih.gov/pubmed/31812677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.113742 |
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