Development and preclinical pharmacology of a novel dCK inhibitor, DI-87

BACKGROUND: Deoxycytidine kinase (dCK) is an essential enzyme for production of nucleotides via the salvage pathway; DI-87 is a novel dCK inhibitor in preclinical development for use in anticancer therapy. The current study utilizes PET imaging to evaluate PK-PD relationships and to determine optima...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Poddar, Soumya, Capparelli, Edmund V., Rosser, Ethan W., Gipson, Raymond M., Wei, Liu, Le, Thuc, Jung, Michael E., Radu, Caius, Nikanjam, Mina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981055/
https://ncbi.nlm.nih.gov/pubmed/31812677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.113742
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