Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion

Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Elliott, Irmina A., Dann, Amanda M., Xu, Shili, Kim, Stephanie S., Abt, Evan R., Kim, Woosuk, Poddar, Soumya, Moore, Alexandra, Zhou, Lei, Williams, Jennifer L., Capri, Joseph R., Ghukasyan, Razmik, Matsumura, Cynthia, Tucker, D. Andrew, Armstrong, Wesley R., Cabebe, Anthony E., Wu, Nanping, Li, Luyi, Le, Thuc M., Radu, Caius G., Donahue, Timothy R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452719/
https://ncbi.nlm.nih.gov/pubmed/30894490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812410116
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