NAD(+) depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition

Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are cr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Moore, Alexandra M., Zhou, Lei, Cui, Jing, Li, Luyi, Wu, Nanping, Yu, Alice, Poddar, Soumya, Liang, Keke, Abt, Evan R., Kim, Stephanie, Ghukasyan, Razmik, Khachatourian, Nooneh, Pagano, Kristina, Elliott, Irmina, Dann, Amanda M., Riahi, Rana, Le, Thuc, Dawson, David W., Radu, Caius G., Donahue, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923374/
https://ncbi.nlm.nih.gov/pubmed/33597293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012469118
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