Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression

Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low argininosuccinate synthetase 1 (ASS1) expression. However, its efficacy as a single agent therapy needs to be improved as resistance is frequently observed. Methods: A tissue microarray was performed to assess ASS1 ex...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Kim, Stephanie S., Xu, Shili, Cui, Jing, Poddar, Soumya, Le, Thuc M., Hayrapetyan, Hovhannes, Li, Luyi, Wu, Nanping, Moore, Alexandra M., Zhou, Lei, Yu, Alice C., Dann, Amanda M., Elliott, Irmina A., Abt, Evan R., Kim, Woosuk, Dawson, David W., Radu, Caius G., Donahue, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929997/
https://ncbi.nlm.nih.gov/pubmed/31903153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.40195
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