Metabolic modifier screen reveals secondary targets of protein kinase inhibitors within nucleotide metabolism

Biosynthesis of the pyrimidine nucleotide uridine monophosphate (UMP) is essential for cell proliferation and is achieved by the activity of convergent de novo and salvage metabolic pathways. Here we report the development and application of a cell-based metabolic modifier screening platform that le...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Abt, Evan R., Rosser, Ethan W., Durst, Matthew A., Lok, Vincent, Poddar, Soumya, Le, Thuc M., Cho, Arthur, Kim, Woosuk, Wei, Liu, Song, Janet, Capri, Joseph R., Xu, Shili, Wu, Nanping, Slavik, Roger, Jung, Michael E., Damoiseaux, Robert, Czernin, Johannes, Donahue, Timothy R., Lavie, Arnon, Radu, Caius G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035983/
https://ncbi.nlm.nih.gov/pubmed/31734178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.012
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge