Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine

Chronic hepatitis B virus (HBV) infection is a major public health problem that affects millions of people worldwide. Nucleoside analogue reverse transcriptase (RT) inhibitors, such as entecavir (ETV) and lamivudine (3TC), serve as crucial anti-HBV drugs. However, structural studies of HBV RT have b...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yasutake, Yoshiaki, Hattori, Shin-ichiro, Tamura, Noriko, Matsuda, Kouki, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033138/
https://ncbi.nlm.nih.gov/pubmed/32080249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59775-w
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