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Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors

[Image: see text] The male rat adrenal pheochromocytoma cell-derived PC12 cell line can synthesize and release catecholamine neurotransmitters, and it has been widely used as a model system in cell biology and toxicology research. Catechol-O-methyltransferase (COMT) is involved in the inactivation o...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Zhang, Gongliang, Buchler, Ingrid P., DePasquale, Michael, Wormald, Michael, Liao, Gangling, Wei, Huijun, Barrow, James C., Carr, Gregory V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032882/
https://ncbi.nlm.nih.gov/pubmed/31491076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00395
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