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IRE1α kinase–mediated unconventional protein secretion rescues misfolded CFTR and pendrin
The most prevalent pathogenic mutations in the CFTR (ΔF508) and SLC26A4/pendrin (p.H723R), which cause cystic fibrosis and congenital hearing loss, respectively, evoke protein misfolding and subsequent defects in their cell surface trafficking. Here, we report that activation of the IRE1α kinase pat...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7030921/ https://ncbi.nlm.nih.gov/pubmed/32128399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9914 |
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