The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion

Mutations in SLC26A4, which encodes pendrin, are responsible for hearing loss with an enlarged vestibular aqueduct and Pendred syndrome. The most prevalent mutation in East Asia is p.H723R (His723Arg), which leads to defects in protein folding and cell-surface expression. Here we show that H723R-pen...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Jung, Jinsei, Kim, Jiyoon, Roh, Shin Hye, Jun, Ikhyun, Sampson, Robert D., Gee, Heon Yung, Choi, Jae Young, Lee, Min Goo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848490/
https://ncbi.nlm.nih.gov/pubmed/27109633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11386
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