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IRE1α kinase–mediated unconventional protein secretion rescues misfolded CFTR and pendrin
The most prevalent pathogenic mutations in the CFTR (ΔF508) and SLC26A4/pendrin (p.H723R), which cause cystic fibrosis and congenital hearing loss, respectively, evoke protein misfolding and subsequent defects in their cell surface trafficking. Here, we report that activation of the IRE1α kinase pat...
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| 發表在: | Sci Adv |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Association for the Advancement of Science
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7030921/ https://ncbi.nlm.nih.gov/pubmed/32128399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9914 |
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