DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins

Cell-to-cell transmission of misfolded proteins propagates proteotoxic stress in multicellular organisms when transmitted polypeptides serve as a seeding template to cause protein misfolding in recipient cells, but how misfolded proteins are released from cells to initiate this process is unclear. M...

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Publicat a:Cell Discov
Autors principals: Xu, Yue, Cui, Lei, Dibello, Anthony, Wang, Lihui, Lee, Juhyung, Saidi, Layla, Lee, Jin-Gu, Ye, Yihong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838229/
https://ncbi.nlm.nih.gov/pubmed/29531792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0012-7
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