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The structure of the infectious prion protein: Experimental data and molecular models

The structures of the infectious prion protein, PrP(Sc), and that of its proteolytically truncated variant, PrP 27–30, have evaded experimental determination due to their insolubility and propensity to aggregate. Molecular modeling has been used to fill this void and to predict their structures, but...

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Опубликовано в: :Prion
Главные авторы: Requena, Jesús R, Wille, Holger
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030906/
https://ncbi.nlm.nih.gov/pubmed/24583975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28368
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