The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

The structure of the infectious prion protein (PrP(Sc)), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrP(Sc) replicates by converting the non-infectious...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Vázquez-Fernández, Ester, Vos, Matthijn R., Afanasyev, Pavel, Cebey, Lino, Sevillano, Alejandro M., Vidal, Enric, Rosa, Isaac, Renault, Ludovic, Ramos, Adriana, Peters, Peter J., Fernández, José Jesús, van Heel, Marin, Young, Howard S., Requena, Jesús R., Wille, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015997/
https://ncbi.nlm.nih.gov/pubmed/27606840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005835
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