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The structure of the infectious prion protein: Experimental data and molecular models

The structures of the infectious prion protein, PrP(Sc), and that of its proteolytically truncated variant, PrP 27–30, have evaded experimental determination due to their insolubility and propensity to aggregate. Molecular modeling has been used to fill this void and to predict their structures, but...

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Detalhes bibliográficos
Publicado no:Prion
Main Authors: Requena, Jesús R, Wille, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030906/
https://ncbi.nlm.nih.gov/pubmed/24583975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28368
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