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The aggregation of mutant p53 produces prion-like properties in cancer
The tumor suppressor protein p53 loses its function in more than 50% of human malignant tumors. Recent studies have suggested that mutant p53 can form aggregates that are related to loss-of-function effects, negative dominance and gain-of-function effects and cancers with a worsened prognosis. In re...
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| Published in: | Prion |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7030899/ https://ncbi.nlm.nih.gov/pubmed/24509441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.27776 |
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