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Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor
p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains; the N-terminal transactivation domain, the CTD (C-terminal domain) and the core domain (p53C) that constitutes the sequence-specific DBD (DNA-b...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Portland Press Ltd.
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728989/ https://ncbi.nlm.nih.gov/pubmed/24003888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20130065 |
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