Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains; the N-terminal transactivation domain, the CTD (C-terminal domain) and the core domain (p53C) that constitutes the sequence-specific DBD (DNA-b...

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Bibliografiska uppgifter
Huvudupphovsmän: Silva, Jerson L., Rangel, Luciana P., Costa, Danielly C. F., Cordeiro, Yraima, De Moura Gallo, Claudia V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2013
Ämnen:
Review Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728989/
https://ncbi.nlm.nih.gov/pubmed/24003888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20130065
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