Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils: IMPLICATIONS FOR CANCER

Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant R248Q could aggregate as amyloids under physiological conditions and whether the mutant could seed aggregation of the wild-type form. The centra...

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Bibliografiske detaljer
Main Authors: Ano Bom, Ana P. D., Rangel, Luciana P., Costa, Danielly C. F., de Oliveira, Guilherme A. P., Sanches, Daniel, Braga, Carolina A., Gava, Lisandra M., Ramos, Carlos H. I., Cepeda, Ana O. T., Stumbo, Ana C., De Moura Gallo, Claudia V., Cordeiro, Yraima, Silva, Jerson L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431633/
https://ncbi.nlm.nih.gov/pubmed/22715097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340638
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