Mammalian prion amyloid formation in bacteria

Mammalian prion proteins (PrPs) that cause transmissible spongiform encephalopathies are misfolded conformations of the host cellular PrP. The misfolded form, the scrapie PrP (PrP(Sc)), can aggregate into amyloid fibrils that progressively accumulate in the brain, evolving to a pathological phenotyp...

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Bibliographic Details
Published in:Prion
Main Authors: Macedo, Bruno, Cordeiro, Yraima, Ventura, Salvador
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981191/
https://ncbi.nlm.nih.gov/pubmed/26910379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2016.1141859
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