The p53 Core Domain Is a Molten Globule at Low pH: FUNCTIONAL IMPLICATIONS OF A PARTIALLY UNFOLDED STRUCTURE

p53 is a transcription factor that maintains genome integrity, and its function is lost in 50% of human cancers. The majority of p53 mutations are clustered within the core domain. Here, we investigate the effects of low pH on the structure of the wild-type (wt) p53 core domain (p53C) and the R248Q...

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Detalhes bibliográficos
Main Authors: Ano Bom, Ana Paula D., Freitas, Monica S., Moreira, Flavia S., Ferraz, Danielly, Sanches, Daniel, Gomes, Andre M. O., Valente, Ana Paula, Cordeiro, Yraima, Silva, Jerson L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807339/
https://ncbi.nlm.nih.gov/pubmed/19933157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075861
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