Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer

The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers, and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An understanding of what triggers the pathogenic amyloid conversion of p53 is required for the further development of cancer t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pedrote, Murilo M., de Oliveira, Guilherme A. P., Felix, Adriani L., Mota, Michelle F., Marques, Mayra de A., Soares, Iaci N., Iqbal, Anwar, Norberto, Douglas R., Gomes, Andre M. O., Gratton, Enrico, Cino, Elio A., Silva, Jerson L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065177/
https://ncbi.nlm.nih.gov/pubmed/29853637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003285
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