Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain

Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical modification, protein-protein interaction, or aggregation has been associated with different human cancers. Although DNA is the typical substrate of p53, numerous studies have reported p53 interactions with RNA. Here, we have...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kovachev, Petar Stefanov, Banerjee, Debapriya, Rangel, Luciana Pereira, Eriksson, Jonny, Pedrote, Murilo M., Martins-Dinis, Mafalda Maria D. C., Edwards, Katarina, Cordeiro, Yraima, Silva, Jerson L., Sanyal, Suparna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454114/
https://ncbi.nlm.nih.gov/pubmed/28420731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762096
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