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RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction

Recent studies have proposed that nucleic acids act as potential cofactors for protein aggregation and prionogenesis. By means of sedimentation, transmission electron microscopy, circular dichroism, static and dynamic light scattering, we have studied how RNA can influence the aggregation of the mur...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kovachev, Petar Stefanov, Gomes, Mariana P. B., Cordeiro, Yraima, Ferreira, Natália C., Valadão, Leticia P. Felix, Ascari, Lucas M., Rangel, Luciana P., Silva, Jerson L., Sanyal, Suparna
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712051/
https://ncbi.nlm.nih.gov/pubmed/31455808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48883-x
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