p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), can restore unfolded p53 mutants to a native conformation that induces apoptosis and activates...

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Vydáno v:J Biol Chem
Hlavní autoři: Rangel, Luciana P., Ferretti, Giulia D. S., Costa, Caroline L., Andrade, Sarah M. M. V., Carvalho, Renato S., Costa, Danielly C. F., Silva, Jerson L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416452/
https://ncbi.nlm.nih.gov/pubmed/30602570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004671
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