p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), can restore unfolded p53 mutants to a native conformation that induces apoptosis and activates...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Rangel, Luciana P., Ferretti, Giulia D. S., Costa, Caroline L., Andrade, Sarah M. M. V., Carvalho, Renato S., Costa, Danielly C. F., Silva, Jerson L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416452/
https://ncbi.nlm.nih.gov/pubmed/30602570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004671
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