Deletion of extra domain A of fibronectin reduces acute myocardial ischemia/reperfusion injury in hyperlipidemic mice by limiting thrombo-inflammation

BACKGROUND: Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for toll-like-receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with comorbid conditions including diabetes and hyperlipidem...

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Bibliographic Details
Published in:Thromb Haemost
Main Authors: Chorawala, Mehul R, Prakash, Prem, Doddapattar, Prakash, Jain, Manish, Dhanesha, Nirav, Chauhan, Anil K.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027995/
https://ncbi.nlm.nih.gov/pubmed/29960272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1661353
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