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Synthetic bPNAs as allosteric triggers of hammerhead ribozyme catalysis

The biochemistry and structural biology of the hammerhead ribozyme (HHR) have been well elucidated. The secondary and tertiary structural elements that enable sugar–phosphate bond scission to be catalyzed by this RNA are clearly understood. We have taken advantage of this knowledge base to test the...

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Publicat a:Methods Enzymol
Autors principals: Liang, Yufeng, Mao, Jie, Bong, Dennis
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023910/
https://ncbi.nlm.nih.gov/pubmed/31239045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.04.028
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