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Small Molecule Recognition Triggers Secondary and Tertiary Interactions in DNA Folding and Hammerhead Ribozyme Catalysis

We have identified tris(2-aminoethyl)amine (tren)-derived scaffolds with two (t2M) or four (t4M) melamine rings that can target oligo T/U domains in DNA/RNA. Unstructured T-rich DNAs cooperatively fold with the tren derivatives to form hairpin-like structures. Both t2M and t4M act as functional swit...

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Publicado en:J Am Chem Soc
Autores principales: Mao, Jie, DeSantis, Chris, Bong, Dennis
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938730/
https://ncbi.nlm.nih.gov/pubmed/28691825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05448
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