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Computational Mutagenesis Studies of Hammerhead Ribozyme Catalysis
Computational studies of the mutational effects at the C3, G8, and G5 positions of the hammerhead ribozyme (HHR) are reported based on a series of twenty four 100-ns molecular dynamics simulations of the native and mutated HHR in the reactant state and in an activated precursor state (G8:2′OH deprot...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948978/ https://ncbi.nlm.nih.gov/pubmed/20812715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105956u |
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