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Computational Mutagenesis Studies of Hammerhead Ribozyme Catalysis

Computational studies of the mutational effects at the C3, G8, and G5 positions of the hammerhead ribozyme (HHR) are reported based on a series of twenty four 100-ns molecular dynamics simulations of the native and mutated HHR in the reactant state and in an activated precursor state (G8:2′OH deprot...

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Autori principali: Lee, Tai-Sung, York, Darrin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948978/
https://ncbi.nlm.nih.gov/pubmed/20812715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105956u
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