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Role of Mg(2+) in Hammerhead Ribozyme Catalysis from Molecular Simulation
Molecular dynamics simulations have been performed to investigate the role of Mg(2+) in the full-length hammerhead ribozyme cleavage reaction. In particular, the aim of this work is to characterize the binding mode and conformational events that give rise to catalytically active conformations and st...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2535817/ https://ncbi.nlm.nih.gov/pubmed/18271579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja076529e |
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