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Context-Sensitive Cleavage of Folded DNAs by Loop-Targeting bPNAs
Herein, we demonstrate context-dependent molecular recognition of DNA by synthetic bPNA iron and copper complexes, using oxidative backbone cleavage as a chemical readout for binding. Oligoethylenimine bPNAs displaying iron·EDTA or copper·phenanthroline sites were found to be efficient chemical nucl...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7477840/ https://ncbi.nlm.nih.gov/pubmed/32519542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00362 |
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