Concise total syntheses of (–)-Jorunnamycin A and (–)-Jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compoun...

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Publicado en:Science
Main Authors: Welin, Eric R., Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M., McDermott, Martina S. J., Conklin, Dylan, Gilmore, Christopher D., Tadross, Pamela M., Haley, Christopher K., Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U., Allan, Kevin M., Virgil, Scott C., Slamon, Dennis J., Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017906/
https://ncbi.nlm.nih.gov/pubmed/30573544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav3421
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