Concise total syntheses of (–)-Jorunnamycin A and (–)-Jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compoun...

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Vydáno v:Science
Hlavní autoři: Welin, Eric R., Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M., McDermott, Martina S. J., Conklin, Dylan, Gilmore, Christopher D., Tadross, Pamela M., Haley, Christopher K., Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U., Allan, Kevin M., Virgil, Scott C., Slamon, Dennis J., Stoltz, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017906/
https://ncbi.nlm.nih.gov/pubmed/30573544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav3421
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