Concise total syntheses of (–)-Jorunnamycin A and (–)-Jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compoun...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Welin, Eric R., Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M., McDermott, Martina S. J., Conklin, Dylan, Gilmore, Christopher D., Tadross, Pamela M., Haley, Christopher K., Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U., Allan, Kevin M., Virgil, Scott C., Slamon, Dennis J., Stoltz, Brian M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017906/
https://ncbi.nlm.nih.gov/pubmed/30573544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav3421
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