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Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of 1,3-Disubstituted Isoquinolines
The development of a general method utilizing a hydroxymethyl directing group for asymmetric hydrogenation of 1,3-disubstituted isoquinolines to provide chiral 1,2,3,4-tetrahydroisoquinolines is reported. The reaction, which utilizes [Ir(cod)Cl](2) and a commercially available chiral xyliphos ligand...
Gorde:
| Argitaratua izan da: | ACS Catal |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8152574/ https://ncbi.nlm.nih.gov/pubmed/34046244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c00211 |
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