Concise total syntheses of (–)-Jorunnamycin A and (–)-Jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compoun...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Welin, Eric R., Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M., McDermott, Martina S. J., Conklin, Dylan, Gilmore, Christopher D., Tadross, Pamela M., Haley, Christopher K., Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U., Allan, Kevin M., Virgil, Scott C., Slamon, Dennis J., Stoltz, Brian M.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017906/
https://ncbi.nlm.nih.gov/pubmed/30573544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav3421
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