Concise total syntheses of (–)-Jorunnamycin A and (–)-Jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compoun...

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Bibliographic Details
Published in:Science
Main Authors: Welin, Eric R., Ngamnithiporn, Aurapat, Klatte, Max, Lapointe, Guillaume, Pototschnig, Gerit M., McDermott, Martina S. J., Conklin, Dylan, Gilmore, Christopher D., Tadross, Pamela M., Haley, Christopher K., Negoro, Kenji, Glibstrup, Emil, Grünanger, Christian U., Allan, Kevin M., Virgil, Scott C., Slamon, Dennis J., Stoltz, Brian M.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017906/
https://ncbi.nlm.nih.gov/pubmed/30573544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav3421
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