Transcriptional Signatures of Tau and Amyloid Neuropathology

Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associate...

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Udgivet i:Cell Rep
Main Authors: Castanho, Isabel, Murray, Tracey K., Hannon, Eilis, Jeffries, Aaron, Walker, Emma, Laing, Emma, Baulf, Hedley, Harvey, Joshua, Bradshaw, Lauren, Randall, Andrew, Moore, Karen, O’Neill, Paul, Lunnon, Katie, Collier, David A., Ahmed, Zeshan, O’Neill, Michael J., Mill, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016505/
https://ncbi.nlm.nih.gov/pubmed/32049030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.063
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