Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

BACKGROUND: Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymethylation...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Hannon, Eilis, Roubroeks, Janou A. Y., Burrage, Joe, Troakes, Claire, Al-Sarraj, Safa, Sloan, Carolyn, Mill, Jonathan, van den Hove, Daniel L., Lunnon, Katie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429761/
https://ncbi.nlm.nih.gov/pubmed/30898171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0636-y
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