Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

BACKGROUND: Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymethylation...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Hannon, Eilis, Roubroeks, Janou A. Y., Burrage, Joe, Troakes, Claire, Al-Sarraj, Safa, Sloan, Carolyn, Mill, Jonathan, van den Hove, Daniel L., Lunnon, Katie
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429761/
https://ncbi.nlm.nih.gov/pubmed/30898171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0636-y
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