Transcriptional Signatures of Tau and Amyloid Neuropathology

Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associate...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Castanho, Isabel, Murray, Tracey K., Hannon, Eilis, Jeffries, Aaron, Walker, Emma, Laing, Emma, Baulf, Hedley, Harvey, Joshua, Bradshaw, Lauren, Randall, Andrew, Moore, Karen, O’Neill, Paul, Lunnon, Katie, Collier, David A., Ahmed, Zeshan, O’Neill, Michael J., Mill, Jonathan
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016505/
https://ncbi.nlm.nih.gov/pubmed/32049030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.063
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