Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma

INTRODUCTION: BRAF V600E and V600K melanomas have distinct clinicopathologic features, and V600K appear to be less responsive to BRAFi+/−MEKi. We investigated mechanisms for this and explored whether genotype affects response to immunotherapy. METHODS: Pre-treatment formalin-fixed paraffin-embedded...

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Publicat a:Clin Cancer Res
Autors principals: da Silva, Inês Pires, Wang, Kevin YX, Wilmott, James S, Holst, Jeff, Carlino, Matteo S, Park, John J, Quek, Camelia, Wongchenko, Matthew, Yan, Yibing, Mann, Graham, Johnson, Douglas B., McQuade, Jennifer L, Rai, Rajat, Kefford, Richard F, Rizos, Helen, Scolyer, Richard A, Yang, Jean YU, Long, Georgina V, Menzies, Alexander M
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015248/
https://ncbi.nlm.nih.gov/pubmed/30630828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1680
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