Clinical significance of intronic variants in BRAF inhibitor resistant melanomas with altered BRAF transcript splicing

Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, located 51 nucleotides upstream of BRAF exon 9 within a predicted splicing branch point. This int...

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Detalles Bibliográficos
Publicado en:Biomark Res
Autores principales: Pupo, Gulietta M., Boyd, Suzanah C., Fung, Carina, Carlino, Matteo S., Menzies, Alexander M., Pedersen, Bernadette, Johansson, Peter, Hayward, Nicholas K., Kefford, Richard F., Scolyer, Richard A., Long, Georgina V., Rizos, Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426037/
https://ncbi.nlm.nih.gov/pubmed/28503307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-017-0098-3
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