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Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries
[Image: see text] Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA–chemical conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that includes a novel aqueous solvent combinat...
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| Pubblicato in: | ACS Comb Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical
Society
2020
|
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7014401/ https://ncbi.nlm.nih.gov/pubmed/31913011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.9b00199 |
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