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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library
DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synth...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7382296/ https://ncbi.nlm.nih.gov/pubmed/32641511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005447117 |
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