Identifying OXA-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries

Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use. β-lactamases that hydrolyze the last resort carbapenem class of β-lactam antibiotics (carbapenemases) are a growing glo...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Taylor, Doris Mia, Anglin, Justin, Park, Suhyeorn, Ucisik, Melek N., Faver, John C., Simmons, Nicholas, Jin, Zhuang, Palaniappan, Murugesan, Nyshadham, Pranavanand, Li, Feng, Campbell, James, Hu, Liya, Sankaran, Banumathi, Prasad, B.V. Venkataram, Huang, Hongbing, Matzuk, Martin M., Palzkill, Timothy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673237/
https://ncbi.nlm.nih.gov/pubmed/32182432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00015
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