Identifying OXA-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries

Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use. β-lactamases that hydrolyze the last resort carbapenem class of β-lactam antibiotics (carbapenemases) are a growing glo...

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Библиографические подробности
Опубликовано в: :ACS Infect Dis
Главные авторы: Taylor, Doris Mia, Anglin, Justin, Park, Suhyeorn, Ucisik, Melek N., Faver, John C., Simmons, Nicholas, Jin, Zhuang, Palaniappan, Murugesan, Nyshadham, Pranavanand, Li, Feng, Campbell, James, Hu, Liya, Sankaran, Banumathi, Prasad, B.V. Venkataram, Huang, Hongbing, Matzuk, Martin M., Palzkill, Timothy
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673237/
https://ncbi.nlm.nih.gov/pubmed/32182432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00015
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