Identifying OXA-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries

Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use. β-lactamases that hydrolyze the last resort carbapenem class of β-lactam antibiotics (carbapenemases) are a growing glo...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Taylor, Doris Mia, Anglin, Justin, Park, Suhyeorn, Ucisik, Melek N., Faver, John C., Simmons, Nicholas, Jin, Zhuang, Palaniappan, Murugesan, Nyshadham, Pranavanand, Li, Feng, Campbell, James, Hu, Liya, Sankaran, Banumathi, Prasad, B.V. Venkataram, Huang, Hongbing, Matzuk, Martin M., Palzkill, Timothy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673237/
https://ncbi.nlm.nih.gov/pubmed/32182432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00015
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