Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries

[Image: see text] Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA–chemical conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that includes a novel aqueous solvent combinat...

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Detalhes bibliográficos
Publicado no:ACS Comb Sci
Main Authors: Monty, Olivier B. C., Nyshadham, Pranavanand, Bohren, Kurt M., Palaniappan, Murugesan, Matzuk, Martin M., Young, Damian W., Simmons, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014401/
https://ncbi.nlm.nih.gov/pubmed/31913011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.9b00199
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