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Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit
OBJECTIVE: Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. METHODS: We generated paired infectious molecular clones (IMCs) for transmitted/founder (T/F)...
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| Udgivet i: | J Infect |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7010540/ https://ncbi.nlm.nih.gov/pubmed/31812703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinf.2019.12.001 |
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