Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit

OBJECTIVE: Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. METHODS: We generated paired infectious molecular clones (IMCs) for transmitted/founder (T/F)...

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Detalhes bibliográficos
Publicado no:J Infect
Main Authors: Wang, Chu, Liu, Donglai, Zuo, Tao, Hora, Bhavna, Cai, Fangping, Ding, Haitao, Kappes, John, Ochsenbauer, Christina, Kong, Wei, Yu, Xianghui, Bhattacharya, Tanmoy, Perelson, Alan S, Gao, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010540/
https://ncbi.nlm.nih.gov/pubmed/31812703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinf.2019.12.001
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