Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8(+) T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus

Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the viruses more fit. However, their impact on viral fitness and their interaction with other immune escape mutations have not been evaluated in the...

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Detalhes bibliográficos
Main Authors: Song, Hongshuo, Hora, Bhavna, Bhattacharya, Tanmoy, Goonetilleke, Nilu, Liu, Michael K. P., Wiehe, Kevin, Li, Hui, Iyer, Shilpa S., McMichael, Andrew J., Perelson, Alan S., Gao, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100905/
https://ncbi.nlm.nih.gov/pubmed/25028937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102734
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