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Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore
The marine polycyclic-ether toxin gambierol and 1-butanol (n-alkanol) inhibit Shaker-type K(v) channels by interfering with the gating machinery. Competition experiments indicated that both compounds do not share an overlapping binding site but gambierol is able to affect 1-butanol affinity for Shak...
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| Veröffentlicht in: | Toxicon |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008702/ https://ncbi.nlm.nih.gov/pubmed/27475861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2016.07.017 |
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